Rabbit anti-Human OBFC1 Polyclonal Antibody

Uniprot Id

Q9H668

Target Species

Human

Target Name

STN1

Target Full Name

CST complex subunit STN1

Target Function

Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins. Required for efficicient replication of the duplex region of the telomere. Promotes efficient replication of lagging-strand telomeres. Promotes general replication start following replication-fork stalling implicating new origin firing. May be in involved in C-strand fill-in during late S/G2 phase independent of its role in telomere duplex replication.; Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites

Target Involvement

Cerebroretinal microangiopathy with calcifications and cysts 2 (CRMCC2)

Target Subcellular Location

Nucleus. Chromosome, telomere.

Target Protein Families

STN1 family

Target Synonyms

AAF 44; AAF44; Alpha accessory factor 44; bA541N10.2; CST complex subunit STN1; FLJ22559; Obfc1; Oligonucleotide/oligosaccharide binding fold containing 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 1; OTTHUMP00000020417; OTTHUMP00000020418; Replication protein A 32 kDa subunit; RP11-541N10.2; RPA 32; STN1; STN1_HUMAN; Suppressor of cdc thirteen; Suppressor of cdc thirteen homolog

Target Background

OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009 [PubMed 19119139]). OBFC1 also appears to function in a telomere-associated complex with C17ORF68 and TEN1 (C17ORF106; MIM 613130) (Miyake et al., 2009 [PubMed 19854130]).