Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
The antibody against BRINP3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 240-500 of human BRINP3 (NP_950252.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against BRINP3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 240-500 of human BRINP3 (NP_950252.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-07235A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BRINP3 |
| Target Synonyms | FAM5C; DBCCR1L; DBCCR1L1; BRINP3 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse brain, U-251MG | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 240-500 of human BRINP3 (NP_950252.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q76B58 | Immunogen Sequence |
Uniprot Id
Q76B58
Target Species
Human
Target Name
BRINP3
Target Full Name
BMP/retinoic acid-inducible neural-specific protein 3
Target Function
Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development.
Target Subcellular Location
Secreted. Mitochondrion.
Target Protein Families
BRINP family
Target Tissue Specificity
Strongly expressed in oral keratinocytes compared to the weak expression in tongue squamous cell carcinoma (SCC). Expressed in endothelial and aortic smooth muscle cells. Overexpressed in gonadotropinomas compared to normal pituitarie tissues.
Target Synonyms
BRINP3; DBCCR1L; DBCCR1L1; FAM5CBMP/retinoic acid-inducible neural-specific protein 3; DBCCR1-like protein 1
Target Background
This gene is overexpressed in pituitary tumors but is underexpressed in tongue squamous cell carcinomas, ulcerative colitis, and peri-implantitis. Polymorphisms that increase expression of this gene have been shown to increase vascular inflammation, and an association of this gene with myocardial infarction has been demonstrated. Finally, hypermethylation of this gene may find usefulness as a biomarker for gastric cancer. Two transcript variants encoding different isoforms have been found for this gene.
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
