Rabbit anti-Human CD42a Polyclonal Antibody

Uniprot Id

P14770

Target Species

Human

Target Name

GP9

Target Full Name

Platelet glycoprotein IX

Target Function

The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.

Target Involvement

Bernard-Soulier syndrome (BSS)

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Synonyms

GP9; Platelet glycoprotein IX; GP-IX; GPIX; Glycoprotein 9; CD antigen CD42a

Target Background

This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency.