Rabbit anti-Human PPFIBP1 Polyclonal Antibody

Uniprot Id

Q86W92

Target Species

Human

Target Name

PPFIBP1

Target Full Name

Liprin-beta-1

Target Function

May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A.

Target Protein Families

Liprin family, Liprin-beta subfamily

Target Tissue Specificity

Widely expressed. Absent in liver.

Target Synonyms

PPFIBP 1; hSGT2; hSgt2p; KIAA1230; L2; LIPB1_HUMAN; Liprin beta 1; liprin related protein; Liprin-beta-1; PPFIBP1; Protein tyrosine phosphatase receptor type f polypeptide interacting protein binding protein 1; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1; PTPRF interacting protein binding protein 1; PTPRF interacting protein; binding protein 1 (liprin beta 1); PTPRF-interacting protein-binding protein 1; SGT2

Target Background

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported.