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The antibody against SEL1L was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 22-190 of human SEL1L (NP_005056.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against SEL1L was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 22-190 of human SEL1L (NP_005056.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
Western blot analysis of various lysates, using SEL1L Rabbit pAb at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 180s.
| Cat.No | ADA-09255A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SEL1L |
| Target Synonyms | Hrd3; SEL1L1; PRO1063; SEL1-LIKE; SEL1L | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse pancreas, U-138MG | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 22-190 of human SEL1L (NP_005056.3). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | SSDEEGSQDESLDSKTTLTSDESVKDHTTAGRVVAGQIFLDSEESELESSIQEEEDSLKSQEGESVTEDISFLESPNPENKDYEEPKKVRKPALTAIEGTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFCETEEEAAKRRQMQEAEMMYQTG | Uniprot ID | Q9UBV2 |
Uniprot Id
Q9UBV2
Target Species
Human
Target Name
SEL1L
Target Full Name
Protein sel-1 homolog 1
Target Function
Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling.
Target Subcellular Location
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Target Protein Families
Sel-1 family
Target Tissue Specificity
Highly expressed in pancreas.
Target Synonyms
IBD2; PRO1063; Protein sel-1 homolog 1; SE1L1_HUMAN; Sel 1 like protein; Sel 1 suppressor of lin 12 like; Sel-1L; SEL1 LIKE; Sel1l; SEL1LIKE; Suppressor of lin-12-like protein 1; TSA305; UNQ128; UNQ128/PRO1063
Target Background
The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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