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The antibody against ECHS1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 28-290 of human ECHS1 (NP_004083.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against ECHS1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 28-290 of human ECHS1 (NP_004083.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-09785A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ECHS1 |
| Target Synonyms | SCEH; mECH; mECH1; ECHS1D; ECHS1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse heart, Rat heart, 293T, Jurkar, Mouse liver, Rat liver | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 28-290 of human ECHS1 (NP_004083.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P30084 | Immunogen Sequence |
Uniprot Id
P30084
Target Species
Human
Target Name
ECHS1
Target Full Name
Enoyl-CoA hydratase, mitochondrial
Target Function
Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate.
Target Involvement
Mitochondrial short-chain enoyl-CoA hydratase 1 deficiency (ECHS1D)
Target Subcellular Location
Mitochondrion matrix.
Target Protein Families
Enoyl-CoA hydratase/isomerase family
Target Tissue Specificity
Liver, fibroblast, muscle. Barely detectable in spleen and kidney.
Target Research Area
Cancer
Target Synonyms
ECHS1Enoyl-CoA hydratase; mitochondrial; EC 4.2.1.17; Enoyl-CoA hydratase 1; Short-chain enoyl-CoA hydratase; SCEH
Target Background
The protein encoded by this gene functions in the second step of the mitochondrial fatty acid beta-oxidation pathway. It catalyzes the hydration of 2-trans-enoyl-coenzyme A (CoA) intermediates to L-3-hydroxyacyl-CoAs. The gene product is a member of the hydratase/isomerase superfamily. It localizes to the mitochondrial matrix. Transcript variants utilizing alternative transcription initiation sites have been described in the literature.
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