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The antibody against MMP11 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 239-488 of human MMP11 (NP_005931.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against MMP11 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 239-488 of human MMP11 (NP_005931.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-11264A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MMP11 |
| Target Synonyms | ST3; SL-3; STMY3; MMP11 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse heart, Mouse kidney, 293T, Mouse lung, Mouse ovary, Mouse skeletal muscle, Raji | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 239-488 of human MMP11 (NP_005931.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P24347 | Immunogen Sequence |
Uniprot Id
P24347
Target Species
Human
Target Name
MMP11
Target Full Name
Stromelysin-3
Target Function
May play an important role in the progression of epithelial malignancies.
Target Subcellular Location
Secreted, extracellular space, extracellular matrix.
Target Protein Families
Peptidase M10A family
Target Tissue Specificity
Specifically expressed in stromal cells of breast carcinomas.
Target Synonyms
Matrix Metalloproteinase 11; Matrix metalloproteinase-11; MMP-11; Mmp11; MMP11_HUMAN; SL 3; SL-3; SL3; ST3; STMY3; Stromelysin 3; Stromelysin III; Stromelysin-3
Target Background
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.
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