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The antibody against US12 was raised in rabbit using the Recombinant Herpes simplex virus type 2 ICP47 protein (US12) (1-78aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Protein G Purified. This antibody has been validated on ELISA, WB.
The antibody against US12 was raised in rabbit using the Recombinant Herpes simplex virus type 2 ICP47 protein (US12) (1-78aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Protein G Purified. This antibody has been validated on ELISA, WB.
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Western Blot | Positive WB detected in Recombinant protein | All lanes: US12 antibody at 1:2000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 28 kDa | Observed band size: 34 kDa
| Cat.No | ADC-55257A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | US12 |
| Target Synonyms | ICP47 protein (Immediate-early protein IE12) (Immediate-early-5) (Infected cell protein 47) (US12 protein) (Vmw12), US12 | Form | Liquid |
| Species Reactivity | Herpes simplex virus type 2 | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Herpes simplex virus type 2 ICP47 protein (US12) (1-78aa) | Target Species | Herpes simplex virus type 2 |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P60504 |
Uniprot Id
P60504
Target Species
Herpes simplex virus type 2
Target Name
US12
Target Function
Plays a role in the inhibition of host immune response. Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules. Empty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.
Target Subcellular Location
Host cytoplasm. Host nucleus.
Target Protein Families
Herpesviridae US12 family
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