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The antibody against ABHD5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-349 of human ABHD5 (NP_057090.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ABHD5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-349 of human ABHD5 (NP_057090.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-11618A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ABHD5 |
| Target Synonyms | CGI58; IECN2; NCIE2; ABHD5 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Jurkat | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-349 of human ABHD5 (NP_057090.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8WTS1 | Immunogen Sequence |
Uniprot Id
Q8WTS1
Target Species
Human
Target Name
ABHD5
Target Full Name
1-acylglycerol-3-phosphate O-acyltransferase ABHD5
Target Function
Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfert of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors. Functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Regulates lipid droplet fusion.
Target Involvement
Chanarin-Dorfman syndrome (CDS)
Target Subcellular Location
Cytoplasm. Lipid droplet. Cytoplasm, cytosol.
Target Protein Families
Peptidase S33 family, ABHD4/ABHD5 subfamily
Target Tissue Specificity
Widely expressed in various tissues, including lymphocytes, liver, skeletal muscle and brain. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and neurons (at protein level).
Target Research Area
Cancer
Target Synonyms
1-acylglycerol-3-phosphate O-acyltransferase ABHD5; ABHD5; ABHD5_HUMAN; Abhydrolase domain containing 5; Abhydrolase domain containing protein 5; Abhydrolase domain-containing protein 5; CDS; CGI 58; CGI58; CGI58 protein; IECN2; Lipid droplet-binding protein CGI-58; MGC8731; NCIE2
Target Background
The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation.
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