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The antibody against ACD was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ACD (NP_001075955.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ACD was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ACD (NP_001075955.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
Western blot analysis of lysates from wild type(WT) and ACD knockdown (KD) 293T(KD) cells, using ACD Rabbit pAb at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 60s.
| Cat.No | ADA-02222A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ACD |
| Target Synonyms | PIP1; PTOP; TPP1; TINT1; ACD | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ACD (NP_001075955.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q96AP0 | Immunogen Sequence |
Uniprot Id
Q96AP0
Target Species
Human
Target Name
ACD
Target Full Name
Adrenocortical dysplasia protein homolog
Target Function
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.
Target Involvement
Dyskeratosis congenita, autosomal dominant, 6 (DKCA6); Dyskeratosis congenita, autosomal recessive, 7 (DKCB7)
Target Subcellular Location
Nucleus. Chromosome, telomere.
Target Synonyms
Acd; ACD_HUMAN; Adrenocortical dysplasia homolog; Adrenocortical dysplasia protein homolog; PIP1; POT1 and TIN2 organizing protein; POT1 and TIN2-interacting protein; TIN2 interacting protein 1; TINT1; TPP1
Target Background
This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I.
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