Rabbit anti-Human ADAM11 Polyclonal Antibody

Uniprot Id

O75078

Target Species

Human

Target Name

ADAM11

Target Full Name

Disintegrin and metalloproteinase domain-containing protein 11

Target Function

Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Tissue Specificity

Expressed predominantly in brain. Slightly detected or not at all in other tissues.

Target Synonyms

MDC; ADAM11

Target Background

This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.