Mouse anti-Human AGK Monoclonal Antibody

Uniprot Id

Q53H12

Target Species

Human

Target Name

AGK

Target Full Name

Acylglycerol kinase, mitochondrial

Target Function

Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Phosphorylates ceramide. Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol. Independently of its lipid kinase activity, acts as a component of the TIM22 complex. The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, required for the import of a subset of metabolite carriers into mitochondria, such as ANT1/SLC25A4 and SLC25A24, while it is not required for the import of TIMM23. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth.

Target Involvement

Mitochondrial DNA depletion syndrome 10 (MTDPS10); Cataract 38 (CTRCT38)

Target Subcellular Location

Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space.

Target Protein Families

AGK family

Target Tissue Specificity

Highly expressed in muscle, heart, kidney and brain.

Target Synonyms

2610037M15Rik; 6720408I04Rik; Acylglycerol Kinase; Acylglycerol kinase mitochondrial; Acylglycerol kinase; mitochondrial; agk; AGK_HUMAN; AI465370; FLJ10842; hAGK; HsMuLK; MuLK; Multi substrate lipid kinase; Multi-substrate lipid kinase; Multiple substrate lipid kinase; RGD1562046

Target Background

The protein encoded by this gene is a mitochondrial membrane protein involved in lipid and glycerolipid metabolism. The encoded protein is a lipid kinase that catalyzes the formation of phosphatidic and lysophosphatidic acids. Defects in this gene have been associated with mitochondrial DNA depletion syndrome 10.