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The antibody against ASB7 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human ASB7 (NP_078984.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ASB7 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human ASB7 (NP_078984.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00183A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ASB7 |
| Target Synonyms | ASB7 | Form | Liquid |
| Species Reactivity | Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse brain | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human ASB7 (NP_078984.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9H672 | Immunogen Sequence |
Uniprot Id
Q9H672
Target Species
Human
Target Name
ASB7
Target Full Name
Ankyrin repeat and SOCS box protein 7
Target Function
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Target Protein Families
Ankyrin SOCS box (ASB) family
Target Synonyms
ASB7Ankyrin repeat and SOCS box protein 7; ASB-7
Target Background
The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described.
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