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The antibody against BAZ1A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1347-1556 of human BAZ1A (NP_038476.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against BAZ1A was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1347-1556 of human BAZ1A (NP_038476.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00891A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BAZ1A |
| Target Synonyms | ACF1; WALp1; hACF1; WCRF180; BAZ1A | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse lung, Mouse spleen, Rat lung, Rat skeletal muscle | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1347-1556 of human BAZ1A (NP_038476.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9NRL2 | Immunogen Sequence |
Uniprot Id
Q9NRL2
Target Species
Human
Target Name
BAZ1A
Target Full Name
Bromodomain adjacent to zinc finger domain protein 1A
Target Function
Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner. The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex. Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex. Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase. May have a role in nuclear receptor-mediated transcription repression.
Target Subcellular Location
Nucleus. Note=May target the CHRAC complex to heterochromatin.
Target Protein Families
WAL family
Target Tissue Specificity
Highly expressed in testis and at low or undetectable levels in other tissues analyzed.
Target Synonyms
Acf1; ACF1; drosophila; homolog of; ATP dependent chromatin remodelling protein; ATP utilizing chromatin assembly and remodeling factor 1; ATP-dependent chromatin-remodeling protein; ATP-utilizing chromatin assembly and remodeling factor 1; B930060C03; Baz1a; BAZ1A_HUMAN; BC065123; Bromodomain adjacent to zinc finger domain 1A; Bromodomain adjacent to zinc finger domain protein 1A; cbp146; CHRAC subunit ACF1; DKFZp586E0518; FLJ14383; Gtl5; hACF1; hWALp1; WALp1; WCRF180; Williams syndrome transcription factor related chromatin remodeling factor 180; Williams syndrome transcription factor-related chromatin-remodeling factor 180
Target Background
The BAZ1A gene encodes the accessory subunit of the ATP-dependent chromatin assembly factor (ACF), a member of the ISWI ('imitation switch') family of chromatin remodeling complexes (summarized by Racki et al., 2009 [PubMed 20033039]).
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