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The antibody against BCLAF1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 330-552 of human BCLAF1 (NP_001070909.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against BCLAF1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 330-552 of human BCLAF1 (NP_001070909.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00263A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BCLAF1 |
| Target Synonyms | BTF; bK211L9.1; BCLAF1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | SH-SY5Y | Application | ELISA, WB |
| Immunogen Description | A synthetic peptide corresponding to a sequence within amino acids 330-552 of human BCLAF1 (NP_001070909.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9NYF8 | Immunogen Sequence |
Uniprot Id
Q9NYF8
Target Species
Human
Target Name
BCLAF1
Target Full Name
Bcl-2-associated transcription factor 1
Target Function
Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.
Target Subcellular Location
Cytoplasm. Nucleus. Nucleus speckle. Nucleus, nucleoplasm.
Target Protein Families
BCLAF1/THRAP3 family
Target Tissue Specificity
Ubiquitous.
Target Synonyms
Bcl 2 associated transcription factor; Bcl-2-associated transcription factor 1; BCL2 associated transcription factor 1; BCLAF1; BCLF1_HUMAN; bK211L9.1; Btf; KIAA0164
Target Background
This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
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