Rabbit anti-Human beta 2 Microglobulin Monoclonal Antibody

Uniprot Id

P61769

Target Species

Human

Target Name

B2M

Target Full Name

Beta-2-microglobulin

Target Function

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation.

Target Involvement

Immunodeficiency 43 (IMD43); Amyloidosis 8 (AMYL8)

Target Subcellular Location

Secreted. Cell surface.;

Target Protein Families

Beta-2-microglobulin family

Target Synonyms

IMD43; beta 2 Microglobulin

Target Background

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.