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The antibody against BMP15 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 143-392 of human BMP15 (NP_005439.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against BMP15 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 143-392 of human BMP15 (NP_005439.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-11773A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BMP15 |
| Target Synonyms | ODG2; POF4; GDF9B; BMP15 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, Rat brain, Mouse brain, Mouse liver, OVCAR3 | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 143-392 of human BMP15 (NP_005439.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O95972 | Immunogen Sequence |
Uniprot Id
O95972
Target Species
Human
Target Name
BMP15
Target Full Name
Bone morphogenetic protein 15
Target Function
May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.
Target Involvement
Ovarian dysgenesis 2 (ODG2); Premature ovarian failure 4 (POF4)
Target Subcellular Location
Secreted.
Target Protein Families
TGF-beta family
Target Research Area
Developmental Biology
Target Synonyms
BMP 15; BMP-15; BMP15; BMP15_HUMAN; Bone morphogenetic protein 15; GDF 9B; GDF-9B; GDF9B; Growth/differentiation factor 9B; ODG2 ; POF4
Target Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure.
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