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The antibody against BRMS1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human BRMS1 (Q9HCU9) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against BRMS1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human BRMS1 (Q9HCU9) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
Western blot analysis of A549, using BRMS1 Rabbit mAb at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 30s.
| Cat.No | ADA-14457A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BRMS1 |
| Target Synonyms | BRMS1; breast cancer metastasis-suppressor 1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | A549 | Application | ELISA, WB, IHC-P |
| Immunogen Description | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human BRMS1 (Q9HCU9). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MPVQPPSKDTEEMEAEGDSAAEMNGEEEESEEERSGSQTESEEESSEMDDEDYERRRSECVSEMLDLEKQFSELKEKLFRERLSQLRLRLEEVGAERAPE | Uniprot ID | Q9HCU9 |
Uniprot Id
Q9HCU9
Target Species
Human
Target Name
BRMS1
Target Full Name
Breast cancer metastasis-suppressor 1
Target Function
Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.
Target Subcellular Location
Nucleus. Cytoplasm. Note=Predominantly nuclear.
Target Protein Families
BRMS1 family
Target Tissue Specificity
Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.
Target Research Area
Apoptosis
Target Synonyms
AV003220; AW554636; Breast cancer metastasis suppressor 1; Breast cancer metastasis-suppressor 1; BRMS1; BRMS1_HUMAN; DKFZp564A063 ; MGC95128
Target Background
This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.
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