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The antibody against C1R was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 466-705 of human C1R (NP_001724.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IF/ICC, ELISA.
The antibody against C1R was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 466-705 of human C1R (NP_001724.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IF/ICC, ELISA.
Immunofluorescence analysis of HeLa cells using C1R antibody. Blue: DAPI for nuclear staining.
| Cat.No | ADA-09499A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | C1R |
| Target Synonyms | EDS8; EDSPD1; C1R | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse bone marrow | Application | ELISA, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 466-705 of human C1R (NP_001724.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P00736 | Immunogen Sequence |
Uniprot Id
P00736
Target Species
Human
Target Name
C1R
Target Full Name
Complement C1r subcomponent
Target Function
C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
Target Involvement
Ehlers-Danlos syndrome, periodontal type, 1 (EDSPD1)
Target Subcellular Location
Secreted.
Target Protein Families
Peptidase S1 family
Target Synonyms
C1 R; C1R; C1R_HUMAN; Complement C1r; Complement C1r subcomponent; Complement C1r subcomponent light chain; Complement C1r subcomponent precursor; Complement component 1 r subcomponent; Complement component 1 subcomponent r
Target Background
This gene encodes a member of the peptidase S1 protein family. The encoded protein is a proteolytic subunit in the complement system C1 complex. The complement system acts as a mediator in the innate immune response by ultimately triggering phagocytosis, inflammation, and rupturing the bacterial cell wall. Mutations in this gene are associated with Ehlers-Danlos Syndrome.
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