Rabbit anti-Human CBLL1 Polyclonal Antibody

The antibody against CBLL1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human CBLL1 (NP_079090.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-05364A

Number

Cat.No	ADA-05364A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	CBLL1
Target Synonyms	HAKAI; RNF188; CBLL1	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse heart, Mouse brain, Mouse lung	Application	ELISA, WB

Cat.No

ADA-05364A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

CBLL1

Target Synonyms

HAKAI; RNF188; CBLL1

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse heart, Mouse brain, Mouse lung

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human CBLL1 (NP_079090.2).	Target Species	Human
Uniprot ID	Q75N03	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human CBLL1 (NP_079090.2).

Target Species

Human

Uniprot ID

Q75N03

Immunogen Sequence

Background Information

Uniprot Id

Q75N03
Target Species

Human
Target Name

CBLL1
Target Full Name

E3 ubiquitin-protein ligase Hakai
Target Function

E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown.
Target Subcellular Location

Nucleus speckle. Nucleus, nucleoplasm. Cytoplasm.
Target Synonyms

c-Cbl-like protein 1; CasBrM (murine) ecotropic retroviral transforming sequencelike 1; Casitas B-lineage lymphoma transforming sequence-like protein 1; Casitas B-lineage lymphoma-like 1; Casitas B-lineage lymphoma-transforming sequence-like protein 1; cbll1; E3 ubiquitin-protein ligase Hakai; Ecadherin binding protein E7; FLJ23109; HAKAI; HAKAI_HUMAN; MGC163401; MGC163403; OTTHUMP00000206720 ; OTTHUMP00000206722 ; OTTHUMP00000206724 ; RING finger protein 188; RNF188
Target Background

This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant.

Rabbit anti-Human CBLL1 Polyclonal Antibody

Specifications

Immunogen Information

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