Rabbit anti-Human CENPQ Polyclonal Antibody

The antibody against CENPQ was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 131-268 of human CENPQ (NP_060602.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-00076A

Number

Cat.No	ADA-00076A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	CENPQ
Target Synonyms	CENP-Q; C6orf139; CENPQ	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Jurkat	Application	ELISA, WB

Cat.No

ADA-00076A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

CENPQ

Target Synonyms

CENP-Q; C6orf139; CENPQ

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Jurkat

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 131-268 of human CENPQ (NP_060602.2).	Target Species	Human
Immunogen Sequence	MEDLTNVSSLLNMERARDKANEEGLALLQEEIDKMVETTELMTGNIQSLKNKIQILASEVEEEEERVKQMHQINSSGVLSLPELSQKTLKAPTLQKEILALIPNQNALLKDLDILHNSSQMKSMSTFIEEAYKKLDAS	Uniprot ID	Q7L2Z9

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 131-268 of human CENPQ (NP_060602.2).

Target Species

Human

Immunogen Sequence

MEDLTNVSSLLNMERARDKANEEGLALLQEEIDKMVETTELMTGNIQSLKNKIQILASEVEEEEERVKQMHQINSSGVLSLPELSQKTLKAPTLQKEILALIPNQNALLKDLDILHNSSQMKSMSTFIEEAYKKLDAS

Uniprot ID

Q7L2Z9

Background Information

Uniprot Id

Q7L2Z9
Target Species

Human
Target Name

CENPQ
Target Full Name

Centromere protein Q
Target Function

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores.
Target Subcellular Location

Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Target Protein Families

CENP-Q/OKP1 family
Target Synonyms

CENP Q; CENP-Q; Cenpq; CENPQ_HUMAN; Centromere protein Q; FLJ10545; OTTHUMP00000016579
Target Background

CENPQ is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).

Rabbit anti-Human CENPQ Polyclonal Antibody

Specifications

Immunogen Information

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