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The antibody against CHIT1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 217-466 of human CHIT1 (NP_003456.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against CHIT1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 217-466 of human CHIT1 (NP_003456.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-09916A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CHIT1 |
| Target Synonyms | CHI3; CHIT; CHITD; CHIT1 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, Mouse skeletal muscle, Mouse spleen, U-251MG | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 217-466 of human CHIT1 (NP_003456.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q13231 | Immunogen Sequence |
Uniprot Id
Q13231
Target Species
Human
Target Name
CHIT1
Target Full Name
Chitotriosidase-1
Target Function
Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.
Target Subcellular Location
Secreted. Lysosome. Note=A small proportion is lysosomal.
Target Protein Families
Glycosyl hydrolase 18 family, Chitinase class II subfamily
Target Tissue Specificity
Detected in spleen. Secreted by cultured macrophages.
Target Synonyms
CHI3; CHIT; CHIT1; CHIT1_HUMAN; CHITD; Chitinase 1; Chitinase 1 (chitotriosidase); Chitinase-1; Chitotriosidase; Chitotriosidase-1; EC 3.2.1.14; FLJ00314; MGC125322; Plasma methylumbelliferyl tetra N acetylchitotetraoside hydrolase
Target Background
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene.
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