Rabbit anti-Human CHRDL1 Polyclonal Antibody

The antibody against CHRDL1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 289-458 of human CHRDL1 (NP_001137453.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-05218A

Number

Cat.No	ADA-05218A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	CHRDL1
Target Synonyms	CHL; MGC1; MGCN; VOPT; NRLN1; dA141H5.1; CHRDL1	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, Mouse heart, Mouse lung	Application	ELISA, WB

Cat.No

ADA-05218A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

CHRDL1

Target Synonyms

CHL; MGC1; MGCN; VOPT; NRLN1; dA141H5.1; CHRDL1

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, Mouse heart, Mouse lung

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 289-458 of human CHRDL1 (NP_001137453.1).	Target Species	Human
Immunogen Sequence	CTCNVTKQECKKIHCPNRYPCKYPQKIDGKCCKVCPGKKAKEELPGQSFDNKGYFCGEETMPVYESVFMEDGETTRKIALETERPPQVEVHVWTIRKGILQHFHIEKISKRMFEELPHFKLVTRTTLSQWKIFTEGEAQISQMCSSRVCRTELEDLVKVLYLERSEKGHC	Uniprot ID	Q9BU40

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 289-458 of human CHRDL1 (NP_001137453.1).

Target Species

Human

Immunogen Sequence

CTCNVTKQECKKIHCPNRYPCKYPQKIDGKCCKVCPGKKAKEELPGQSFDNKGYFCGEETMPVYESVFMEDGETTRKIALETERPPQVEVHVWTIRKGILQHFHIEKISKRMFEELPHFKLVTRTTLSQWKIFTEGEAQISQMCSSRVCRTELEDLVKVLYLERSEKGHC

Uniprot ID

Q9BU40

Background Information

Uniprot Id

Q9BU40
Target Species

Human
Target Name

CHRDL1
Target Full Name

Chordin-like protein 1
Target Function

Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation. May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development.
Target Involvement

Megalocornea 1, X-linked (MGC1)
Target Subcellular Location

Secreted.
Target Tissue Specificity

Expressed in the developing cornea and in the eye anterior segment in addition to the retina. Differentially expressed in the fetal brain. There is high expression in cerebellum and neocortex. Expressed in retinal pericytes.
Target Synonyms

CHL; chordin like 1; Chordin-like protein 1; CHRDL1; CRDL1_HUMAN; dA141H5.1; neuralin 1; Neuralin-1; Neurogenesin-1; NRLN1; Ventroptin; VOPT
Target Background

This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described.

Rabbit anti-Human CHRDL1 Polyclonal Antibody

Specifications

Immunogen Information

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