Rabbit anti-Human CLEC4G Polyclonal Antibody

Uniprot Id

Q6UXB4

Target Species

Human

Target Name

CLEC4G

Target Full Name

C-type lectin domain family 4 member G

Target Function

Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner, in vitro.; (Microbial infection) Acts as a receptor for Japanese encephalitis virus.; (Microbial infection) Acts as a receptor for Ebolavirus.; (Microbial infection) Acts as a receptor for SARS-CoV.; (Microbial infection) Acts as a receptor for Lassa virus and Lymphocytic choriomeningitis virus glycoprotein.

Target Subcellular Location

Cell membrane; Single-pass type II membrane protein.

Target Tissue Specificity

Expressed exclusively in fetal and adult liver and in lymph nodes. Specifically expressed by endothelial cells lining lymph node and liver sinuses (at protein level).

Target Synonyms

C type lectin domain family 4; member G; C type lectin superfamily 4; member G; C-type lectin domain family 4 member G; CLC4G_HUMAN; Clec4g; DTTR431; Liver and lymph node sinusoidal endothelial cell C type lectin; LP2698; LSECtin; UNQ431

Target Background

This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the immune response. C-type lectin receptors are pattern recognition receptors located on immune cells that play a role in the recognition and uptake of both self and non-self glycoproteins as well as mediating cell adhesion, glycoprotein clearance, and cell signaling functions. This gene's protein binds complex-type N-glycans of the viral envelope proteins of Ebola virus, West Nile filovirus, and SARS coronavirus, but not HIV or hepatitis C virus. In mouse, this protein has been shown to recognize activated T-cells and to negatively regulate T-cell receptor-mediated signalling. It also acts as a novel, liver-specific regulator of NK cell-mediated immunity in mouse. Multiple transcript variants encoding different isoforms have been found for this gene.