Rabbit anti-Human CLN8 Polyclonal Antibody

The antibody against CLN8 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 200-286 of human CLN8 (NP_061764.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-03907A

Number

Cat.No	ADA-03907A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	CLN8
Target Synonyms	EPMR; TLCD6; C8orf61; CLN8	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, K-562, LO2, SKOV3	Application	ELISA, WB, IHC-P

Cat.No

ADA-03907A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

CLN8

Target Synonyms

EPMR; TLCD6; C8orf61; CLN8

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, K-562, LO2, SKOV3

Application

ELISA, WB, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 200-286 of human CLN8 (NP_061764.2).	Target Species	Human
Immunogen Sequence	MFHCRMVLTYHMWWVCFWHWDGLVSSLYLPHLTLFLVGLALLTLIINPYWTHKKTQQLLNPVDWNFAQPEAKSRPEGNGQLLRKKRP	Uniprot ID	Q9UBY8

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 200-286 of human CLN8 (NP_061764.2).

Target Species

Human

Immunogen Sequence

MFHCRMVLTYHMWWVCFWHWDGLVSSLYLPHLTLFLVGLALLTLIINPYWTHKKTQQLLNPVDWNFAQPEAKSRPEGNGQLLRKKRP

Uniprot ID

Q9UBY8

Background Information

Uniprot Id

Q9UBY8
Target Species

Human
Target Name

CLN8
Target Full Name

Protein CLN8
Target Function

Could play a role in cell proliferation during neuronal differentiation and in protection against cell death.
Target Involvement

Ceroid lipofuscinosis, neuronal, 8 (CLN8); Ceroid lipofuscinosis, neuronal, 8, Northern epilepsy variant (CLN8NE)
Target Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Endoplasmic reticulum.
Target Synonyms

CLN8; C8orf61; Protein CLN8
Target Background

This gene encodes a transmembrane protein belonging to a family of proteins containing TLC domains, which are postulated to function in lipid synthesis, transport, or sensing. The protein localizes to the endoplasmic reticulum (ER), and may recycle between the ER and ER-Golgi intermediate compartment. Mutations in this gene are associated with a disorder characterized by progressive epilepsy with cognitive disabilities (EPMR), which is a subtype of neuronal ceroid lipofuscinoses (NCL). Patients with mutations in this gene have altered levels of sphingolipid and phospholipids in the brain.

Rabbit anti-Human CLN8 Polyclonal Antibody

Specifications

Immunogen Information

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