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The antibody against CNTRL was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 250-500 of human CNTRL (NP_008949.4) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against CNTRL was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 250-500 of human CNTRL (NP_008949.4) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05249A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CNTRL |
| Target Synonyms | FAN; CEP1; CEP110; bA165P4.1; CNTRL | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse lung, Mouse spleen, Raji | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 250-500 of human CNTRL (NP_008949.4). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q7Z7A1 | Immunogen Sequence |
Uniprot Id
Q7Z7A1
Target Species
Human
Target Name
CNTRL
Target Full Name
Centriolin
Target Function
Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission.
Target Involvement
A chromosomal aberration involving CEP110 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(8;9)(p12;q33) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein CEP110-FGFR1 is found in the cytoplasm, exhibits constitutive kinase activity and may be responsible for the transforming activity.
Target Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody, Midbody ring.
Target Tissue Specificity
Widely expressed with highest levels in testis and trachea.
Target Synonyms
CNTRL; CEP1; CEP110Centriolin; Centrosomal protein 1; Centrosomal protein of 110 kDa; Cep110
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