Rabbit anti-Human COX7A1 Polyclonal Antibody

Uniprot Id

P24310

Target Species

Human

Target Name

COX7A1

Target Full Name

Cytochrome c oxidase subunit 7A1, mitochondrial

Target Function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Target Subcellular Location

Mitochondrion inner membrane; Single-pass membrane protein.

Target Protein Families

Cytochrome c oxidase VIIa family

Target Synonyms

COX7A; COX7A1; COX7AH; COX7AM; CX7A1_HUMAN; Cytochrome c oxidase subunit 7A1; Cytochrome c oxidase subunit 7A1 mitochondrial; Cytochrome c oxidase subunit VIIa H; Cytochrome c oxidase subunit VIIa heart; Cytochrome c oxidase subunit VIIa heart/muscle isoform; Cytochrome c oxidase subunit VIIa M; Cytochrome c oxidase subunit VIIa muscle; Cytochrome c oxidase subunit VIIa polypeptide 1 (muscle); Cytochrome c oxidase subunit VIIa polypeptide 1; Cytochrome c oxidase subunit VIIa-H; Cytochrome c oxidase subunit VIIa-heart; Cytochrome c oxidase subunit VIIa-M; Cytochrome c oxidase subunit VIIa-muscle; mitochondrial

Target Background

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (muscle isoform) of subunit VIIa and the polypeptide 1 is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes.