Rabbit anti-Human CYP26B1 Polyclonal Antibody

Uniprot Id

Q9NR63

Target Species

Human

Target Name

CYP26B1

Target Full Name

Cytochrome P450 26B1

Target Function

Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.; Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo.

Target Involvement

Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)

Target Subcellular Location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Target Protein Families

Cytochrome P450 family

Target Tissue Specificity

Highly expressed in brain, particularly in the cerebellum and pons.

Target Research Area

Cardiovascular

Target Synonyms

CP26; CP26B_HUMAN; CYP26A2; cyp26b1; Cytochrome P450 26A2; Cytochrome P450 26B1; Cytochrome P450 family 26 subfamily B polypeptide 1; Cytochrome P450 retinoic acid-inactivating 2; Cytochrome P450 retinoid metabolizing protein; Cytochrome P450 subfamily XXVIA; polypeptide 2; Cytochrome P450 subfamily XXVIB polypeptide 1; Cytochrome P450RAI-2; DKFZp686G0638; dol; EC 1.14.; fc21d03; MGC129613; P450 26A2; P450 retinoic acid inactivating 2; P450RAI 2; P450RAI2; Retinoic acid metabolizing cytochrome; Retinoic acid-metabolizing cytochrome; RHFCA; stocksteif; wu:fc21d03; wu:fc26h10; zgc:76999

Target Background

This gene encodes a member of the cytochrome P450 superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein is localized to the endoplasmic reticulum, and functions as a critical regulator of all-trans retinoic acid levels by the specific inactivation of all-trans retinoic acid to hydroxylated forms. Mutations in this gene are associated with radiohumeral fusions and other skeletal and craniofacial anomalies, and increased levels of the encoded protein are associated with atherosclerotic lesions. Alternative splicing results in multiple transcript variants.