Rabbit anti-Human D2HGDH Polyclonal Antibody

The antibody against D2HGDH was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 322-521 of human D2HGDH (NP_689996.4) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-04562A

Number

Cat.No	ADA-04562A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	d2hgdh
Target Synonyms	D2HGD; D2HGDH	Form	Liquid
Species Reactivity	Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	Rat heart, Mouse liver	Application	ELISA, WB

Cat.No

ADA-04562A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

d2hgdh

Target Synonyms

D2HGD; D2HGDH

Form

Liquid

Species Reactivity

Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

Rat heart, Mouse liver

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 322-521 of human D2HGDH (NP_689996.4).	Target Species	Human
Immunogen Sequence	GRHLHLASPVQESPFYVLIETSGSNAGHDAEKLGHFLEHALGSGLVTDGTMATDQRKVKMLWALRERITEALSRDGYVYKYDLSLPVERLYDIVTDLRARLGPHAKHVVGYGHLGDGNLHLNVTAEAFSPSLLAALEPHVYEWTAGQQGSVSAEHGVGFRKRDVLGYSKPPGALQLMQQLKALLDPKGILNPYKTLPSQA	Uniprot ID	Q8N465

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 322-521 of human D2HGDH (NP_689996.4).

Target Species

Human

Immunogen Sequence

GRHLHLASPVQESPFYVLIETSGSNAGHDAEKLGHFLEHALGSGLVTDGTMATDQRKVKMLWALRERITEALSRDGYVYKYDLSLPVERLYDIVTDLRARLGPHAKHVVGYGHLGDGNLHLNVTAEAFSPSLLAALEPHVYEWTAGQQGSVSAEHGVGFRKRDVLGYSKPPGALQLMQQLKALLDPKGILNPYKTLPSQA

Uniprot ID

Q8N465

Background Information

Uniprot Id

Q8N465
Target Species

Human
Target Name

D2HGDH
Target Full Name

D-2-hydroxyglutarate dehydrogenase, mitochondrial
Target Function

Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC.
Target Involvement

D-2-hydroxyglutaric aciduria 1 (D2HGA1)
Target Subcellular Location

Mitochondrion.
Target Protein Families

FAD-binding oxidoreductase/transferase type 4 family
Target Research Area

Metabolism
Target Synonyms

D2HGDH; D2HGDD-2-hydroxyglutarate dehydrogenase; mitochondrial; EC 1.1.99.-
Target Background

This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features.

Rabbit anti-Human D2HGDH Polyclonal Antibody

Specifications

Immunogen Information

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