Rabbit anti-Human DCDC2 Polyclonal Antibody

Uniprot Id

Q9UHG0

Target Species

Human

Target Name

DCDC2

Target Full Name

Doublecortin domain-containing protein 2

Target Function

Protein that plays a role in the inhibition of canonical Wnt signaling pathway. May be involved in neuronal migration during development of the cerebral neocortex. Involved in the control of ciliogenesis and ciliary length.

Target Involvement

Dyslexia 2 (DYX2); Nephronophthisis 19 (NPHP19); Deafness, autosomal recessive, 66 (DFNB66); Sclerosing cholangitis, neonatal (NSC)

Target Subcellular Location

Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, kinocilium. Cytoplasm, cytoskeleton.

Target Tissue Specificity

Ubiquitously expressed. In brain, highly expressed in the entorhinal cortex, inferior temporal cortex, medial temporal cortex, hypothalamus, amygdala and hippocampus. Expressed in liver by cholangiocytes, the epithelial cells of the bile ducts (at protein

Target Synonyms

DCDC 2; DCDC2; DCDC2_HUMAN; DCDC2A; Doublecortin domain containing 2; doublecortin domain containing protein 2; Doublecortin domain-containing protein 2; HGNC:18141; KIAA1154; Protein RU2S; RU 2; RU2; RU2S; RU2S protein

Target Background

This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene.