Rabbit anti-Human DGKZ Polyclonal Antibody

Uniprot Id

Q13574

Target Species

Human

Target Name

DGKZ

Target Full Name

Diacylglycerol kinase zeta

Target Function

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids. Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group. The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol. By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization. Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane.; Regulates RASGRP1 activity.; Does not regulate RASGRP1 activity.

Target Subcellular Location

Nucleus. Cytoplasm, cytosol. Cell membrane. Cell projection, lamellipodium.

Target Protein Families

Eukaryotic diacylglycerol kinase family

Target Tissue Specificity

Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas.; [Isoform 2]: Predominantly expressed in muscle.

Target Synonyms

DAG kinase zeta; DAGK5 ; DAGK5 PEN; DAGK6 ; DGK ZETA ; DGK-zeta; Dgkz; DGKZ_HUMAN; Diacylglycerol kinase zeta; Diglyceride kinase zeta; hDGKzeta

Target Background

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified.