Rabbit anti-Human DMRT1 Polyclonal Antibody

Uniprot Id

Q9Y5R6

Target Species

Human

Target Name

DMRT1

Target Full Name

Doublesex- and mab-3-related transcription factor 1

Target Function

Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis.

Target Involvement

Testicular germ cell tumor (TGCT); 46,XY sex reversal 4 (SRXY4)

Target Subcellular Location

Nucleus.

Target Protein Families

DMRT family

Target Tissue Specificity

Testis-specific. Expressed in prostate cancer (at protein level).

Target Synonyms

CT154; DM domain expressed in testis 1; DM domain expressed in testis protein 1; DM domain gene expressed in testis; DMRT 1; dmrt1; DMRT1_HUMAN; DMT 1; DMT1; Doublesex and mab 3 related transcription factor 1; Doublesex- and mab-3-related transcription factor 1

Target Background

This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous.