Rabbit anti-Human DMT1/SLC11A2 Monoclonal Antibody

The antibody against DMT1/SLC11A2 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 300-400 of human DMT1/SLC11A2 (NP_000608.1) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, IP, ELISA.

ADA-16408A

Number

Cat.No	ADA-16408A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	DMT1/SLC11A2
Target Synonyms	DCT1; DMT1; AHMIO1; NRAMP2; DMT1/SLC11A2	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.05% proclin300, pH7.3.	Purification Method	Affinity purification
Positive Samples	293F	Application	ELISA, WB, IF/ICC, IP

Cat.No

ADA-16408A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

DMT1/SLC11A2

Target Synonyms

DCT1; DMT1; AHMIO1; NRAMP2; DMT1/SLC11A2

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.05% proclin300, pH7.3.

Purification Method

Affinity purification

Positive Samples

293F

Application

ELISA, WB, IF/ICC, IP

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 300-400 of human DMT1/SLC11A2 (NP_000608.1)	Target Species	Human
Immunogen Sequence	SCIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTSSPHAGLFPKDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEG	Uniprot ID	P49281

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 300-400 of human DMT1/SLC11A2 (NP_000608.1)

Target Species

Human

Immunogen Sequence

SCIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTSSPHAGLFPKDNSTLAVDIYKGGVVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEG

Uniprot ID

P49281

Background Information

Uniprot Id

P49281
Target Species

Human
Target Name

SLC11A2
Target Full Name

Natural resistance-associated macrophage protein 2
Target Function

Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria.
Target Involvement

Anemia, hypochromic microcytic, with iron overload 1 (AHMIO1)
Target Subcellular Location

[Isoform 2]: Cell membrane; Multi-pass membrane protein. Early endosome.; Endosome membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Target Protein Families

NRAMP family
Target Tissue Specificity

Ubiquitously expressed. Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in spleen, thymus and pancreas. Isoform 3 and isoform 4 are abundantly expressed in duodenum and kidney.
Target Synonyms

DCT 1; dct-1; DCT1; Divalent cation transporter 1; Divalent metal transporter 1; DMT 1; DMT-1; DMT1; FLJ37416; Natural resistance associated macrophage protein 2; Natural resistance-associated macrophage protein 2; NRAM2_HUMAN; NRAMP 2; NRAMP2; OK/SW-cl.20; Slc11a2; Solute carrier family 11 (proton coupled divalent metal ion transporters) member 2; Solute carrier family 11 member 2
Target Background

This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.

Rabbit anti-Human DMT1/SLC11A2 Monoclonal Antibody

Specifications

Immunogen Information

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