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The antibody against DPEP2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 400-463 of human DPEP2 (NP_071750.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against DPEP2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 400-463 of human DPEP2 (NP_071750.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05010A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DPEP2 |
| Target Synonyms | MBD2; DPEP2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse spleen, Rat spleen | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 400-463 of human DPEP2 (NP_071750.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | VEKVQEENKWQSPLEDKFPDEQLSSSCHSDLSRLRQRQSLTSGQELTEIPIHWTAKLPAKWSVS | Uniprot ID | Q9H4A9 |
Uniprot Id
Q9H4A9
Target Species
Human
Target Name
DPEP2
Target Full Name
Dipeptidase 2
Target Function
Dipeptidase that hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4). Does not hydrolyze cystinyl-bis-glycine.; Independently of its dipeptidase activity can also modulate macrophage inflammatory response by acting as a regulator of NF-kappaB inflammatory signaling pathway.
Target Subcellular Location
Membrane; Lipid-anchor, GPI-anchor.
Target Protein Families
Metallo-dependent hydrolases superfamily, Peptidase M19 family
Target Research Area
Cancer
Target Synonyms
DPEP2; UNQ284/PRO323Dipeptidase 2; EC 3.4.13.19
Target Background
DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al., 2003 [PubMed 12738806]).
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