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The antibody against DSG2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 635-935 of human DSG2 (NP_001934.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against DSG2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 635-935 of human DSG2 (NP_001934.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-07686A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DSG2 |
| Target Synonyms | HDGC; CDHF5; DSG2 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, DU-145, Hep G2, K-562, SW620 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 635-935 of human DSG2 (NP_001934.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q14126 | Immunogen Sequence |
Uniprot Id
Q14126
Target Species
Human
Target Name
DSG2
Target Full Name
Desmoglein-2
Target Function
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Target Involvement
Arrhythmogenic right ventricular dysplasia, familial, 10 (ARVD10); Cardiomyopathy, dilated 1BB (CMD1BB)
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
Target Tissue Specificity
All of the tissues tested and carcinomas.
Target Research Area
Others
Target Synonyms
ARVC 10; ARVC10; ARVD 10; ARVD10; Cadherin family member 5; CDHF 5; CDHF5; CMD1BB; Desmoglein 2; Desmoglein-2; Desmoglein2; DSG 2; DSG2; DSG2_HUMAN; HDGC; HDGC included; Human Desmoglein colon; MGC117034; MGC117036; MGC117037
Target Background
This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10.
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