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The antibody against DYNC1I2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 352-612 of human DYNC1I2 (NP_001258717.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against DYNC1I2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 352-612 of human DYNC1I2 (NP_001258717.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05487A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DYNC1I2 |
| Target Synonyms | IC2; DIC74; DNCI2; NEDMIBA; DYNC1I2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, Mouse testis, SH-SY5Y, U-251MG | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 352-612 of human DYNC1I2 (NP_001258717.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q13409 | Immunogen Sequence |
Uniprot Id
Q13409
Target Species
Human
Target Name
DYNC1I2
Target Full Name
Cytoplasmic dynein 1 intermediate chain 2
Target Function
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.
Target Subcellular Location
Cytoplasm, cytoskeleton. Cytoplasm.
Target Protein Families
Dynein intermediate chain family
Target Synonyms
Cytoplasmic dynein 1 intermediate chain 2; Cytoplasmic dynein intermediate chain 2; cytosolic; DC1I2_HUMAN; DH IC 2 ; DH IC-2; DNCI2 ; DNCIC2 ; Dync1i2; Dynein intermediate chain 2; Dynein intermediate chain 2; cytosolic; Dynein; cytoplasmic; intermediate polypeptide 2 ; IC2
Target Background
This gene encodes a member of the dynein intermediate chain family. The encoded protein is a non-catalytic component of the cytoplasmic dynein 1 complex, which acts as a retrograde microtubule motor to transport organelles and vesicles. A pseudogene of this gene is located on chromosome 10. Alternative splicing results in multiple transcript variants.
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