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The antibody against ECSIT was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 50-296 of human ECSIT (NP_001135936.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against ECSIT was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 50-296 of human ECSIT (NP_001135936.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-12091A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ECSIT |
| Target Synonyms | SITPEC; ECSIT | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HepG2 | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 50-296 of human ECSIT (NP_001135936.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9BQ95 | Immunogen Sequence |
Uniprot Id
Q9BQ95
Target Species
Human
Target Name
ECSIT
Target Full Name
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
Target Function
Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development.; Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.
Target Subcellular Location
Cytoplasm. Nucleus. Mitochondrion.
Target Protein Families
ECSIT family
Target Synonyms
Ecsit; ECSIT homolog; ECSIT protein; ECSIT_HUMAN; Evolutionarily conserved signaling intermediate in Toll pathway; mitochondrial; Evolutionarily conserved signaling intermediate in Toll pathways; Likely ortholog of mouse signaling intermediate in Toll pathway evolutionarily conserved; Protein SITPEC; Signaling intermediate in Toll pathway evolutionarily conserved; SITPEC; SITPEC protein
Target Background
Predicted to enable DNA-binding transcription factor activity and chromatin binding activity. Involved in regulation of oxidoreductase activity and regulation of protein complex stability. Located in cytosol; mitochondrion; and nucleoplasm.
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