Rabbit anti-Human EDF1 Polyclonal Antibody

The antibody against EDF1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-148 of human EDF1 (NP_003783.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-13459A

Number

Cat.No	ADA-13459A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	EDF1
Target Synonyms	MBF1; EDF-1; CFAP280; F1	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	NIH/3T3, Rat brain, HepG2, Mouse brain, Mouse liver	Application	ELISA, WB, IHC-P

Cat.No

ADA-13459A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

EDF1

Target Synonyms

MBF1; EDF-1; CFAP280; F1

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

NIH/3T3, Rat brain, HepG2, Mouse brain, Mouse liver

Application

ELISA, WB, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-148 of human EDF1 (NP_003783.1).	Target Species	Human
Immunogen Sequence	MAESDWDTVTVLRKKGPTAAQAKSKQAILAAQRRGEDVETSKKWAAGQNKQHSITKNTAKLDRETEELHHDRVTLEVGKVIQQGRQSKGLTQKDLATKINEKPQVIADYESGRAIPNNQVLGKIERAIGLKLRGKDIGKPIEKGPRAK	Uniprot ID	O60869

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-148 of human EDF1 (NP_003783.1).

Target Species

Human

Immunogen Sequence

MAESDWDTVTVLRKKGPTAAQAKSKQAILAAQRRGEDVETSKKWAAGQNKQHSITKNTAKLDRETEELHHDRVTLEVGKVIQQGRQSKGLTQKDLATKINEKPQVIADYESGRAIPNNQVLGKIERAIGLKLRGKDIGKPIEKGPRAK

Uniprot ID

O60869

Background Information

Uniprot Id

O60869
Target Species

Human
Target Name

EDF1
Target Full Name

Endothelial differentiation-related factor 1
Target Function

Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.
Target Subcellular Location

Cytoplasm. Nucleus. Note=Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin.
Target Tissue Specificity

Expressed in brain, liver, lung, kidney and heart (at protein level). Ubiquitously expressed. More abundant in heart, pancreas, liver, intestine and adipose tissues.
Target Synonyms

CAP19; EDF-1; edf1; EDF1_HUMAN; Endothelial differentiation related factor 1 ; Endothelial differentiation-related factor 1; MBF1; MGC9058; Multiprotein bridging factor 1; Multiprotein-bridging factor 1
Target Background

This gene encodes a protein that may regulate endothelial cell differentiation, lipid metabolism, and hormone-induced cardiomyocyte hypertrophy. The encoded protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Alternate splicing results in multiple transcript variants.

Rabbit anti-Human EDF1 Polyclonal Antibody

Specifications

Immunogen Information

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