Rabbit anti-Human EDN3 Polyclonal Antibody

Uniprot Id

P14138

Target Species

Human

Target Name

EDN3

Target Full Name

Endothelin-3

Target Function

Endothelins are endothelium-derived vasoconstrictor peptides.

Target Involvement

Hirschsprung disease 4 (HSCR4); Congenital central hypoventilation syndrome (CCHS); Waardenburg syndrome 4B (WS4B)

Target Subcellular Location

Secreted.

Target Protein Families

Endothelin/sarafotoxin family

Target Tissue Specificity

Expressed in trophoblasts and placental stem villi vessels, but not in cultured placental smooth muscle cells.

Target Research Area

Cancer

Target Synonyms

EDN3; EDN3_HUMAN; Endothelin 3; Endothelin-3; ET 3; ET-3; PPET3; Preproendothelin 3; Preproendothelin-3

Target Background

The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms.