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The antibody against FHL3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human FHL3 (NP_004459.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against FHL3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human FHL3 (NP_004459.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-01131A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FHL3 |
| Target Synonyms | SLIM2; FHL3 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HL-60, HT-1080, LO2, Mouse skeletal muscle | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human FHL3 (NP_004459.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q13643 | Immunogen Sequence |
Uniprot Id
Q13643
Target Species
Human
Target Name
FHL3
Target Full Name
Four and a half LIM domains protein 3
Target Function
Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.
Target Subcellular Location
Nucleus. Cytoplasm.
Target Tissue Specificity
Expressed only in skeletal muscle.
Target Research Area
Tags & Cell Markers
Target Synonyms
FHL 3; FHL-3; Fhl3; FHL3_HUMAN; Four and a half LIM domains 3; Four and a half LIM domains protein 3; Skeletal muscle LIM protein 2; Skeletal muscle LIM-protein 2; SLIM-2; SLIM2
Target Background
The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene.
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