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The antibody against GAS6 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human GAS6 (NP_000811.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against GAS6 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human GAS6 (NP_000811.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-12066A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GAS6 |
| Target Synonyms | AXSF; AXLLG; GAS6 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, DU145, HT-1080, NCI-H460, SW620 | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human GAS6 (NP_000811.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q14393 | Immunogen Sequence |
Uniprot Id
Q14393
Target Species
Human
Target Name
GAS6
Target Full Name
Growth arrest-specific protein 6
Target Function
Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.; (Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry. Plays a role in Dengue cell entry by apoptotic mimicry. Plays a role in Vaccinia virus cell entry by apoptotic mimicry. Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry.
Target Subcellular Location
Secreted.
Target Tissue Specificity
Plasma. Isoform 1 and isoform 2 are widely expressed, isoform 1 being expressed at higher levels than isoform 2 in most tissues. Isoform 2 is the predominant form in spleen.
Target Research Area
Cardiovascular
Target Synonyms
AXL receptor tyrosine kinase ligand; AXL stimulatory factor; AXLLG; AXS F; AXSF; DKFZp666G247; FLJ34709; Gas 6; GAS-6; Gas6; GAS6_HUMAN; Growth arrest specific 6; Growth arrest-specific protein 6; Growth-arrest-specific protein 6; Growth-arrest-specific protein 6 precursor
Target Background
This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia.
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