Rabbit anti-Human GJA8 Polyclonal Antibody

The antibody against GJA8 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 234-433 of human GJA8 (NP_005258.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.

ADA-10622A

Number

Cat.No	ADA-10622A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	GJA8
Target Synonyms	CAE; CAE1; CX50; CZP1; MP70; CTRCT1; GJA8	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	Raji	Application	ELISA, WB, IF/ICC

Cat.No

ADA-10622A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

GJA8

Target Synonyms

CAE; CAE1; CX50; CZP1; MP70; CTRCT1; GJA8

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

Raji

Application

ELISA, WB, IF/ICC

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 234-433 of human GJA8 (NP_005258.2).	Target Species	Human
Immunogen Sequence	SALKRPVEQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLPAKPFNQFEEKISTGPLGDLSRGYQETLPSYAQVGAQEVEGEGPPAEEGAEPEVGEKKEEAERLTTEEQEKVAVPEGEKVETPGVDKEGEKEEPQSEKVSKQGLPAEKTPSLCPELTTDDARPLSRLSKASSRARSDDLTV	Uniprot ID	P48165

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 234-433 of human GJA8 (NP_005258.2).

Target Species

Human

Immunogen Sequence

SALKRPVEQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLPAKPFNQFEEKISTGPLGDLSRGYQETLPSYAQVGAQEVEGEGPPAEEGAEPEVGEKKEEAERLTTEEQEKVAVPEGEKVETPGVDKEGEKEEPQSEKVSKQGLPAEKTPSLCPELTTDDARPLSRLSKASSRARSDDLTV

Uniprot ID

P48165

Background Information

Uniprot Id

P48165
Target Species

Human
Target Name

GJA8
Target Full Name

Gap junction alpha-8 protein
Target Function

Structural component of eye lens gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.
Target Involvement

Cataract 1, multiple types (CTRCT1)
Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Target Protein Families

Connexin family, Alpha-type (group II) subfamily
Target Tissue Specificity

Eye lens.
Target Synonyms

GJA8; Gap junction alpha-8 protein; Connexin-50; Cx50; Lens fiber protein MP70
Target Background

This gene encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. The encoded protein is a component of gap junction channels and functions in a calcium and pH-dependent manner. Mutations in this gene have been associated with zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome.

Rabbit anti-Human GJA8 Polyclonal Antibody

Specifications

Immunogen Information

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