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The antibody against GP6/GPVI was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 21-267 of human GP6/GPVI (NP_057447.5) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on FC, ELISA.
The antibody against GP6/GPVI was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 21-267 of human GP6/GPVI (NP_057447.5) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on FC, ELISA.
Flow cytometry: 1X10^6 MOLT-4 cells (negative control, left)?and HEL cells (right) were surface-stained with GP6/GPVI Rabbit mAb or ABflo? 594 Rabbit IgG isotype control, followed by ABflo? 594-conjugated Goat Anti-Rabbit IgG (H+L) staining. Non-fluorescently stained cells were used as blank control (red line).
| Cat.No | ADA-15676A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GP6/GPVI |
| Target Synonyms | GPIV; GPVI; BDPLT11; GP6/GPVI | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, 0.05% BSA, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, FC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 21-267 of human GP6/GPVI (NP_057447.5). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9HCN6 | Immunogen Sequence |
Uniprot Id
Q9HCN6
Target Species
Human
Target Name
GP6
Target Full Name
Platelet glycoprotein VI
Target Function
Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.
Target Involvement
Bleeding disorder, platelet-type 11 (BDPLT11)
Target Subcellular Location
[Isoform 1]: Cell membrane; Single-pass membrane protein.; [Isoform 2]: Cell membrane; Single-pass membrane protein.
Target Tissue Specificity
Megakaryocytes and platelets.
Target Synonyms
Glycoprotein 6; Glycoprotein VI; GP6; GPIV; GPVI; GPVI_HUMAN; MGC138168; Platelet collagen receptor; Platelet glycoprotein VI; Platelet glycoprotein VI precursor
Target Background
This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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