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The antibody against GPRASP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 200-500 of human GPRASP1 (NP_055525.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against GPRASP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 200-500 of human GPRASP1 (NP_055525.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-10007A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GPRASP1 |
| Target Synonyms | GASP; GASP1; GASP-1; GPRASP1 | Form | Liquid |
| Species Reactivity | Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat eye, Rat testis | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 200-500 of human GPRASP1 (NP_055525.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q5JY77 | Immunogen Sequence |
Uniprot Id
Q5JY77
Target Species
Human
Target Name
GPRASP1
Target Full Name
G-protein coupled receptor-associated sorting protein 1
Target Function
Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2.
Target Subcellular Location
Cytoplasm.
Target Protein Families
GPRASP family
Target Tissue Specificity
Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra.
Target Synonyms
G-protein coupled receptor-associated sorting protein 1; GASP; GASP-1; GASP1; GASP1_HUMAN; Gprasp1; KIAA0443
Target Background
This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified.
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