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Rabbit anti-Human ICAM5 Polyclonal Antibody

The antibody against ICAM5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 32-180 of human ICAM5 (NP_003250.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-09764A

The antibody against ICAM5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 32-180 of human ICAM5 (NP_003250.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

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Specifications


Cat.No ADA-09764A ClonalityPolyclonal
Host SpeciesRabbitTarget NameICAM5
Target SynonymsTLN; TLCN; ICAM5FormLiquid
Species ReactivityHuman, Mouse, RatIsotypeIgG
Storage Buffer50% Glycerol, PBS with 0.02% sodium azide, pH7.3.Purification MethodAffinity purification
Positive SamplesMouse brain, Rat testisApplicationELISA, WB

Immunogen Information


Immunogen DescriptionRecombinant fusion protein containing a sequence corresponding to amino acids 32-180 of human ICAM5 (NP_003250.3).Target SpeciesHuman
Immunogen SequenceEPFWADLQPRVAFVERGGSLWLNCSTNCPRPERGGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFRCARRTLQARGLIRTFQRPDRVELMPLPPWQPVGENFTLSCRVPGAGPRASLTLTLLRGAQELIRRSFAGEPPRARGAVUniprot IDQ9UMF0
Background Information
  • Uniprot Id

    Q9UMF0

  • Target Species

    Human

  • Target Name

    ICAM5

  • Target Full Name

    Intercellular adhesion molecule 5

  • Target Function

    ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).

  • Target Subcellular Location

    Membrane; Single-pass type I membrane protein.

  • Target Protein Families

    Immunoglobulin superfamily, ICAM family

  • Target Tissue Specificity

    Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon.

  • Target Synonyms

    ICAM5; TLCN; TLNIntercellular adhesion molecule 5; ICAM-5; Telencephalin

  • Target Background

    The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.

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