Rabbit anti-Human IL5RA Polyclonal Antibody

Uniprot Id

Q01344

Target Species

Human

Target Name

IL5RA

Target Full Name

Interleukin-5 receptor subunit alpha

Target Function

This is the receptor for interleukin-5. The alpha chain binds to IL5.

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

Type I cytokine receptor family, Type 5 subfamily

Target Tissue Specificity

Expressed on eosinophils and basophils.

Target Synonyms

IL5R; CD125; CDw125; HSIL5R3; IL5RA

Target Background

The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported.