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The antibody against KBTBD8 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 50-280 of human KBTBD8 (NP_115894.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against KBTBD8 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 50-280 of human KBTBD8 (NP_115894.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-07305A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KBTBD8 |
| Target Synonyms | TAKRP; TA-KRP; KBTBD8 | Form | Liquid |
| Species Reactivity | Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat lung | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 50-280 of human KBTBD8 (NP_115894.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8NFY9 | Immunogen Sequence |
Uniprot Id
Q8NFY9
Target Species
Human
Target Name
KBTBD8
Target Full Name
Kelch repeat and BTB domain-containing protein 8
Target Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification.
Target Subcellular Location
Cytoplasm, cytoskeleton, spindle. Golgi apparatus.
Target Protein Families
KBTBD8 family
Target Synonyms
AU040152; FLJ57592; KBTB8_HUMAN; Kbtbd8; Kelch repeat and BTB (POZ) domain containing 8 ; Kelch repeat and BTB domain containing protein 8; Kelch repeat and BTB domain-containing protein 8; KIAA1842; MGC91215; mKIAA1842; OTTHUMP00000213470; RGD1563166; SSEC 51; SSEC51; T cell activation kelch repeat protein; T-cell activation Kelch repeat protein; TA KRP; TA-KRP; Takrp
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