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The antibody against KDM4B/JMJD2B was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-365 of human KDM4B/JMJD2B (NP_055830.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against KDM4B/JMJD2B was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-365 of human KDM4B/JMJD2B (NP_055830.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-10713A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KDM4B/JMJD2B |
| Target Synonyms | MRD65; JMJD2B; TDRD14B; KDM4B/JMJD2B | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse brain | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-365 of human KDM4B/JMJD2B (NP_055830.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O94953 | Immunogen Sequence |
Uniprot Id
O94953
Target Species
Human
Target Name
KDM4B
Target Full Name
Lysine-specific demethylase 4B
Target Function
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.
Target Subcellular Location
Nucleus.
Target Protein Families
JHDM3 histone demethylase family
Target Synonyms
JHDM3B; JmjC domain-containing histone demethylation protein 3B; JMJD2B; Jumonji domain containing 2B; Jumonji domain containing protein 2B; Jumonji domain-containing protein 2B; Kdm4b; KDM4B_HUMAN; KIAA0876; Lysine (K) specific demethylase 4B; Lysine demethylase 4B; Lysine-specific demethylase 4B; TDRD14B; Tudor domain containing 14B
Target Background
Enables histone H3-methyl-lysine-36 demethylase activity and histone H3-methyl-lysine-9 demethylase activity. Involved in histone H3-K36 demethylation and histone H3-K9 demethylation. Located in cytosol and nucleoplasm. Implicated in autosomal dominant non-syndromic intellectual disability; breast cancer; colorectal cancer; malignant peripheral nerve sheath tumor; and stomach cancer. Biomarker of several diseases, including alopecia areata; lung cancer; medulloblastoma; prostate cancer; and stomach cancer.
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