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The antibody against LIFR/CD118 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 45-833 of human LIFR/CD118 (NP_002301.1) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on FC, ELISA.
The antibody against LIFR/CD118 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 45-833 of human LIFR/CD118 (NP_002301.1) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on FC, ELISA.
Flow cytometry: 1X10^6 REH cells (negative control, left) and HeLa cells (right) were surface-stained with LIFR/CD118 Rabbit mAb or ABflo? 647 Rabbit IgG isotype control, followed by Alexa Fluor? 647 conjugated goat anti-rabbit pAb staining. Non-fluorescently stained cells were used as blank control (red line).
| Cat.No | ADA-15647A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | LIFR/CD118 |
| Target Synonyms | SWS; SJS2; STWS; CD118; LIF-R; LIFR/CD118 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, 0.05% BSA, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, FC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 45-833 of human LIFR/CD118 (NP_002301.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P42702 | Immunogen Sequence |
Uniprot Id
P42702
Target Species
Human
Target Name
LIFR
Target Full Name
Leukemia inhibitory factor receptor
Target Function
Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.
Target Involvement
Stueve-Wiedemann syndrome (STWS)
Target Subcellular Location
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
Target Protein Families
Type I cytokine receptor family, Type 2 subfamily
Target Synonyms
CD118; CD118 antigen; FLJ98106; FLJ99923; Leukemia inhibitory factor receptor alpha; Leukemia inhibitory factor receptor; LIF R; LIF receptor; LIF-R; Lifr; LIFR_HUMAN; SJS2 ; STWS ; SWS
Target Background
This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding two different isoforms have been found for this gene.
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