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The antibody against LPIN2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 180-400 of human LPIN2 (NP_055461.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against LPIN2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 180-400 of human LPIN2 (NP_055461.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-04854A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | LPIN2 |
| Target Synonyms | LPIN2; lipin 2 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, 293T, A-549, DU145, LO2, Mouse liver, Mouse lung, Mouse spleen | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 180-400 of human LPIN2 (NP_055461.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q92539 | Immunogen Sequence |
Uniprot Id
Q92539
Target Species
Human
Target Name
LPIN2
Target Full Name
Phosphatidate phosphatase LPIN2
Target Function
Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism.
Target Involvement
Majeed syndrome (MJDS)
Target Subcellular Location
Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum membrane.
Target Protein Families
Lipin family
Target Tissue Specificity
Expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon.
Target Synonyms
KIAA0249; Lipin-2; Lipin2; LPIN 2; LPIN2; LPIN2_HUMAN; OTTHUMP00000162242; Phosphatidate phosphatase LPIN2
Target Background
Mouse studies suggest that this gene functions during normal adipose tissue development and may play a role in human triglyceride metabolism. This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance.
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